ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are key regulators of the apoptotic process. This family comprises proapoptotic and prosurvival proteins, and shifting the balance toward the latter is an established mechanism whereby cancer cells evade apoptosis. The therapeutic potential of dir...

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Bibliographic Details
Main Authors: Hymowitz, Sarah G., Jin, Sha, Khaw, Seong Lin, Kovar, Peter J., Lam, Lloyd T., Lee, Jackie, Maecker, Heather L., Marsh, Kennan C., Mason, Kylie D., Mitten, Michael J., Sampath, Deepak, Nimmer, Paul M., Oleksijew, Anatol, Park, Chang H., Park, Cheol-Min, Phillips, Darren C., Roberts, Andrew W., Seymour, John F., Smith, Morey L., Sullivan, Gerard M., Tahir, Stephen K., Wendt, Michael D., Xiao, Yu, Xue, John C., Zhang, Haichao, Humerickhouse, Rod A., Rosenberg, Saul H., Elmore, Steven W., Tse, Chris, Souers, Andrew J., Leverson, Joel D., Boghaert, Erwin R., Ackler, Scott L., Catron, Nathaniel D., Chen, Jun, Dayton, Brian D., Ding, Hong, Enschede, Sari H., Fairbrother, Wayne J., Huang, David C. S.
Other Authors: School of Physical and Mathematical Sciences
Format: Journal Article
Language:English
Published: 2013
Subjects:
DRNTU::Science::Chemistry::Biochemistry
Online Access:https://hdl.handle.net/10356/107357
http://hdl.handle.net/10220/18024
http://dx.doi.org/10.1038/nm.3048

Internet

https://hdl.handle.net/10356/107357
http://hdl.handle.net/10220/18024
http://dx.doi.org/10.1038/nm.3048

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