The impact of membrane composition on conformation and trafficking of lipidated prion protein (PrP) variants
Prion protein (PrP) aggregation arises from the misfolding of the native cellular PrP (PrPC) and is a key pathophysiologic event in fatal neurodegenerative prion diseases. To elucidate the mechanism of conversion of PrPC into toxic PrPSc, homogeneous PrP constructs carrying a glycosylphosphatidylino...
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| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
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Nanyang Technological University
2020
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| Online Access: | https://hdl.handle.net/10356/136871 |