The impact of membrane composition on conformation and trafficking of lipidated prion protein (PrP) variants

The impact of membrane composition on conformation and trafficking of lipidated prion protein (PrP) variants

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Prion protein (PrP) aggregation arises from the misfolding of the native cellular PrP (PrPC) and is a key pathophysiologic event in fatal neurodegenerative prion diseases. To elucidate the mechanism of conversion of PrPC into toxic PrPSc, homogeneous PrP constructs carrying a glycosylphosphatidylino...

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Bibliographic Details
Main Author:	Hackl, Stefanie
Other Authors:	Cho Nam-Joon
Format:	Thesis-Doctor of Philosophy
Language:	English
Published:	Nanyang Technological University 2020
Subjects:	Engineering::Chemical engineering::Biochemical engineering
Online Access:	https://hdl.handle.net/10356/136871

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