Loss of Parkin impairs mitochondrial function and leads to muscle atrophy

Parkinson's disease is a neurodegenerative disease characterized by tremors, muscle stiffness, and muscle weakness. Molecular genetic analysis has confirmed that mutations in PARKIN and PINK1 genes, which play major roles in mitochondrial quality control and mitophagy, are frequently associated...

Full description

Bibliographic Details
Main Authors: Peker, Nesibe, Donipadi, Vinay, Sharma, Mridula, McFarlane, Craig, Kambadur, Ravi
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2020
Subjects:
Online Access:https://hdl.handle.net/10356/138111