Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin
Produced by a newly isolated Streptomycetes strain, meijiemycin is a gigantic linear polyene-polyol that exhibits structural features not seen in other members of the polyene-polyol family. We propose a biosynthetic mechanism and demonstrate that meijiemycin inhibits hyphal growth by inducing the ag...
| Main Authors: | , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/138959 |
| _version_ | 1811687241888563200 |
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| author | Low, Zhen Jie Xiong, Juan Xie, Ying Ma, Guang-Lei Saw, Howard Tran, Hoa Thi Wong, Soo Lin Pang, Li Mei Fong, July Lu, Peng Hu, Jin-Feng Liang, Yang Miao, Yansong Liang, Zhao-Xun |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Low, Zhen Jie Xiong, Juan Xie, Ying Ma, Guang-Lei Saw, Howard Tran, Hoa Thi Wong, Soo Lin Pang, Li Mei Fong, July Lu, Peng Hu, Jin-Feng Liang, Yang Miao, Yansong Liang, Zhao-Xun |
| author_sort | Low, Zhen Jie |
| collection | NTU |
| description | Produced by a newly isolated Streptomycetes strain, meijiemycin is a gigantic linear polyene-polyol that exhibits structural features not seen in other members of the polyene-polyol family. We propose a biosynthetic mechanism and demonstrate that meijiemycin inhibits hyphal growth by inducing the aggregation of ergosterol and restructuring of the fungal plasma membrane. |
| first_indexed | 2024-10-01T05:13:11Z |
| format | Journal Article |
| id | ntu-10356/138959 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:13:11Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1389592022-03-17T05:13:33Z Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin Low, Zhen Jie Xiong, Juan Xie, Ying Ma, Guang-Lei Saw, Howard Tran, Hoa Thi Wong, Soo Lin Pang, Li Mei Fong, July Lu, Peng Hu, Jin-Feng Liang, Yang Miao, Yansong Liang, Zhao-Xun School of Biological Sciences Singapore Centre for Environmental Life Sciences and Engineering Science::Biological sciences::Biochemistry Science::Biological sciences::Microbiology Natural Product Anti-fungal Agent Produced by a newly isolated Streptomycetes strain, meijiemycin is a gigantic linear polyene-polyol that exhibits structural features not seen in other members of the polyene-polyol family. We propose a biosynthetic mechanism and demonstrate that meijiemycin inhibits hyphal growth by inducing the aggregation of ergosterol and restructuring of the fungal plasma membrane. NRF (Natl Research Foundation, S’pore) MOE (Min. of Education, S’pore) Accepted version 2020-05-14T05:54:55Z 2020-05-14T05:54:55Z 2019 Journal Article Low, Z. J., Xiong, J., Xie, Y., Ma, G.-L., Saw, H., Tran, H. T., . . . Liang, Z.-X. (2020). Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin. Chemical Communications, 56(5), 822-825. doi:10.1039/c9cc08908j 1359-7345 https://hdl.handle.net/10356/138959 10.1039/c9cc08908j 5 56 822 825 en NRF-SBP-01 Chemical Communications © 2020 The Royal Society of Chemistry. All rights reserved. This paper was published in Chemical Communications and is made available with permission of The Royal Society of Chemistry. application/pdf |
| spellingShingle | Science::Biological sciences::Biochemistry Science::Biological sciences::Microbiology Natural Product Anti-fungal Agent Low, Zhen Jie Xiong, Juan Xie, Ying Ma, Guang-Lei Saw, Howard Tran, Hoa Thi Wong, Soo Lin Pang, Li Mei Fong, July Lu, Peng Hu, Jin-Feng Liang, Yang Miao, Yansong Liang, Zhao-Xun Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin |
| title | Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin |
| title_full | Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin |
| title_fullStr | Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin |
| title_full_unstemmed | Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin |
| title_short | Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin |
| title_sort | discovery biosynthesis and antifungal mechanism of the polyene polyol meijiemycin |
| topic | Science::Biological sciences::Biochemistry Science::Biological sciences::Microbiology Natural Product Anti-fungal Agent |
| url | https://hdl.handle.net/10356/138959 |
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