The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity

The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity

In eukaryotes, pyridoxal kinase (PDXK) acts in vitamin B6 salvage pathway to produce pyridoxal 5'-phosphate (PLP), the active form of the vitamin, which is implicated in numerous crucial metabolic reactions. In Drosophila, mutations in the dPdxk gene cause chromosome aberrations (CABs) and incr...

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Bibliographic Details
Main Authors: Mascolo, Elisa, Barile, Anna, Mecarelli, Lorenzo Stufera, Amoroso, Noemi, Merigliano, Chiara, Massimi, Arianna, Saggio, Isabella, Hansen, Torben, Tramonti, Angela, Di Salvo, Martino Luigi, Barbetti, Fabrizio, Contestabile, Roberto, Vernì, Fiammetta
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2020
Subjects:
Science::Biological sciences
Pyridoxal Kinase (PDXK)
Online Access:https://hdl.handle.net/10356/142344

Internet

https://hdl.handle.net/10356/142344

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