Nucleic acid structure and conjugation for drug design
Nucleic acids can adopt diverse secondary structures, one of which is the four-stranded G-quadruplex (G4). The G4s have been widely studied as anticancer targets where their stabilization by ligands were shown to impact downstream biological processes. Recent discoveries of G4 sub-types, such as qua...
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| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
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Nanyang Technological University
2020
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| Online Access: | https://hdl.handle.net/10356/143056 |