Mechanism and application of oxygen-independent photocleavage of blebbistatin as a blue or near-infrared light-gated hydroxyl radical photocage
Development of versatile, chemically tunable photocages for photoactivated chemotherapy (PACT) represents an excellent opportunity to address the technical drawbacks of conventional photodynamic therapy (PDT) whose oxygen-dependent nature renders it inadequate in certain therapy contexts such as hyp...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Conference Paper |
| Language: | English |
| Published: |
2020
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| Online Access: | https://hdl.handle.net/10356/144190 |
| _version_ | 1826120118047866880 |
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| author | Li, Ming-De Wong, Nai-Kei Huang, Guanheng Chen, Xuebo Yang, Dan Phillips, David Lee |
| author2 | Asian Spectroscopy Conference 2020 |
| author_facet | Asian Spectroscopy Conference 2020 Li, Ming-De Wong, Nai-Kei Huang, Guanheng Chen, Xuebo Yang, Dan Phillips, David Lee |
| author_sort | Li, Ming-De |
| collection | NTU |
| description | Development of versatile, chemically tunable photocages for photoactivated chemotherapy (PACT) represents an excellent opportunity to address the technical drawbacks of conventional photodynamic therapy (PDT) whose oxygen-dependent nature renders it inadequate in certain therapy contexts such as hypoxic tumors. As an alternative to PDT, oxygen free mechanisms to generate cytotoxic reactive oxygen species (ROS) by visible light cleavable photocages are in demand. Here, we report the detailed mechanisms by which the small molecule blebbistatin acts as a one-photon blue light-gated or two-photon nearinfrared light-gated photocage to directly release a hydroxyl radical (•OH) in the absence of oxygen. |
| first_indexed | 2024-10-01T05:10:57Z |
| format | Conference Paper |
| id | ntu-10356/144190 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:10:57Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1441902020-10-22T20:10:53Z Mechanism and application of oxygen-independent photocleavage of blebbistatin as a blue or near-infrared light-gated hydroxyl radical photocage Li, Ming-De Wong, Nai-Kei Huang, Guanheng Chen, Xuebo Yang, Dan Phillips, David Lee Asian Spectroscopy Conference 2020 Institute of Advanced Studies Science::Chemistry Photocage Blebbistatin Development of versatile, chemically tunable photocages for photoactivated chemotherapy (PACT) represents an excellent opportunity to address the technical drawbacks of conventional photodynamic therapy (PDT) whose oxygen-dependent nature renders it inadequate in certain therapy contexts such as hypoxic tumors. As an alternative to PDT, oxygen free mechanisms to generate cytotoxic reactive oxygen species (ROS) by visible light cleavable photocages are in demand. Here, we report the detailed mechanisms by which the small molecule blebbistatin acts as a one-photon blue light-gated or two-photon nearinfrared light-gated photocage to directly release a hydroxyl radical (•OH) in the absence of oxygen. Published version 2020-10-20T02:41:14Z 2020-10-20T02:41:14Z 2020 Conference Paper Li, M.-D., Wong, N.-K., Huang, G., Chen, X., Yang, D., & Phillips, D. L. (2020). Mechanism and application of oxygen-independent photocleavage of blebbistatin as a blue or near-infrared light-gated hydroxyl radical photocage. Proceedings of the 7th Asian Spectroscopy Conference 2020 (ASC 2020). doi:10.32655/ASC_8-10_Dec2020.6 https://hdl.handle.net/10356/144190 10.32655/ASC_8-10_Dec2020.6 en © 2020 Nanyang Technological University. application/pdf |
| spellingShingle | Science::Chemistry Photocage Blebbistatin Li, Ming-De Wong, Nai-Kei Huang, Guanheng Chen, Xuebo Yang, Dan Phillips, David Lee Mechanism and application of oxygen-independent photocleavage of blebbistatin as a blue or near-infrared light-gated hydroxyl radical photocage |
| title | Mechanism and application of oxygen-independent photocleavage of blebbistatin as a blue or near-infrared light-gated hydroxyl radical photocage |
| title_full | Mechanism and application of oxygen-independent photocleavage of blebbistatin as a blue or near-infrared light-gated hydroxyl radical photocage |
| title_fullStr | Mechanism and application of oxygen-independent photocleavage of blebbistatin as a blue or near-infrared light-gated hydroxyl radical photocage |
| title_full_unstemmed | Mechanism and application of oxygen-independent photocleavage of blebbistatin as a blue or near-infrared light-gated hydroxyl radical photocage |
| title_short | Mechanism and application of oxygen-independent photocleavage of blebbistatin as a blue or near-infrared light-gated hydroxyl radical photocage |
| title_sort | mechanism and application of oxygen independent photocleavage of blebbistatin as a blue or near infrared light gated hydroxyl radical photocage |
| topic | Science::Chemistry Photocage Blebbistatin |
| url | https://hdl.handle.net/10356/144190 |
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