HCAR1/MCT1 regulates tumor ferroptosis through the lactate-mediated AMPK-SCD1 activity and its therapeutic implications

HCAR1/MCT1 regulates tumor ferroptosis through the lactate-mediated AMPK-SCD1 activity and its therapeutic implications

Ferroptosis is a recently discovered form of programed cell death caused by the metabolically regulated lipid peroxidation and holds promise for cancer treatment, but its regulatory mechanisms remain elusive. In this study, we observe that lactate-rich liver cancer cells exhibit enhanced resistance...

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Bibliographic Details
Main Authors: Zhao, Youbo, Li, Menghuan, Yao, Xuemei, Fei, Yang, Lin, Zhenghong, Li, Zhengguo, Cai, Kaiyong, Zhao, Yanli, Luo, Zhong
Other Authors: School of Physical and Mathematical Sciences
Format: Journal Article
Language:English
Published: 2021
Subjects:
Science::Chemistry
Lactate
Ferroptosis
Online Access:https://hdl.handle.net/10356/146149

Internet

https://hdl.handle.net/10356/146149

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