Conserved sequence motifs in human TMTC1, TMTC2, TMTC3, and TMTC4, new O-mannosyltransferases from the GT-C/PMT clan, are rationalized as ligand binding sites

Background: The human proteins TMTC1, TMTC2, TMTC3 and TMTC4 have been experimentally shown to be components of a new O-mannosylation pathway. Their own mannosyl-transferase activity has been suspected but their actual enzymatic potential has not been demonstrated yet. So far, sequence analysis of T...

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Detalhes bibliográficos
Main Authors: Eisenhaber, Birgit, Sinha, Swati, Jadalanki, Chaitanya K., Shitov, Vladimir A., Tan, Qiao Wen, Sirota, Fernanda L., Eisenhaber, Frank
Outros Autores: School of Biological Sciences
Formato: Journal Article
Idioma:English
Publicado em: 2021
Assuntos:
Acesso em linha:https://hdl.handle.net/10356/146664