Antibody neutralization of microbiota-derived circulating peptidoglycan dampens inflammation and ameliorates autoimmunity

Antibody neutralization of microbiota-derived circulating peptidoglycan dampens inflammation and ameliorates autoimmunity

The human microbiota provides tonic signals that calibrate the host immune response1,2, but their identity is unknown. Bacterial peptidoglycan (PGN) subunits are likely candidates since they are well-known immunity-enhancing adjuvants, released by most bacteria during growth, and have been found in...

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Bibliographic Details
Main Authors: Huang, Zhenxing, Wang, Jianhe, Xu, Xiaoli, Wang, Haishan, Qiao, Yuan, Chu, Wern Cui, Xu, Shengli, Chai, Louis, Cottier, Fabien, Pavelka, Norman, Oosting, Marije, Joosten, Leo A. B., Netea, Mihai, Ng, Carol Yee Leng, Leong, Khai Pang, Kundu, Parag, Lam, Kong-Peng, Pettersson, Sven, Wang, Yue
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2021
Subjects:
Science::Medicine
Antimicrobial Responses
Autoimmune Diseases
Online Access:https://hdl.handle.net/10356/147107

Internet

https://hdl.handle.net/10356/147107

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