Towards understanding of PRC2 binding to RNA
Polycomb repressive complex 2 (PRC2) and its methylation of histone 3 at lysine 27 (H3K27me3) play a crucial role in epigenetic regulation of normal development and malignancy. Several factors regulate the recruitment of PRC2 and affects its chromatin modification function. Over the past years, emer...
| Main Authors: | , , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2021
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/147827 |
| _version_ | 1826124372474068992 |
|---|---|
| author | Yan, Junli Dutta, Bibek Hee, Yan Ting Chng, Wee-Joo |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Yan, Junli Dutta, Bibek Hee, Yan Ting Chng, Wee-Joo |
| author_sort | Yan, Junli |
| collection | NTU |
| description | Polycomb repressive complex 2 (PRC2) and its methylation of histone 3 at lysine 27 (H3K27me3) play a crucial role in epigenetic regulation of normal development and malignancy. Several factors regulate the recruitment of PRC2 and affects its chromatin modification function. Over the past years, emerging discoveries have portrayed the association of RNA (protein-coding and non-coding) with PRC2 as a critical factor in understanding PRC2 function. With PRC2 being a macromolecular complex of interest in development and diseases, further studies are needed to relate the rapidly evolving PRC2:RNA biology in that scenario. In this review, we summarize the current understanding of different modes of RNA binding by PRC2, and further discuss perspectives, key questions and therapeutic applications of PRC2 binding to RNAs. |
| first_indexed | 2024-10-01T06:19:34Z |
| format | Journal Article |
| id | ntu-10356/147827 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:19:34Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1478272021-04-12T07:35:44Z Towards understanding of PRC2 binding to RNA Yan, Junli Dutta, Bibek Hee, Yan Ting Chng, Wee-Joo Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Polycomb Repressive Complex 2 Chromatin Polycomb repressive complex 2 (PRC2) and its methylation of histone 3 at lysine 27 (H3K27me3) play a crucial role in epigenetic regulation of normal development and malignancy. Several factors regulate the recruitment of PRC2 and affects its chromatin modification function. Over the past years, emerging discoveries have portrayed the association of RNA (protein-coding and non-coding) with PRC2 as a critical factor in understanding PRC2 function. With PRC2 being a macromolecular complex of interest in development and diseases, further studies are needed to relate the rapidly evolving PRC2:RNA biology in that scenario. In this review, we summarize the current understanding of different modes of RNA binding by PRC2, and further discuss perspectives, key questions and therapeutic applications of PRC2 binding to RNAs. Ministry of Education (MOE) National Medical Research Council (NMRC) This study is supported by the National Medical Research Council (NMRC) Grants NMRC/CIRG/1343/2012 (W.-J. Chng), NMRC/BNIG/2021/2014 (J. Yan), the RNA Biology Center at CSI Singapore, NUS, as part of funding under the Singapore Ministry of Education’s Tier 3 grant MOE2014-T3-1-006, and the Singapore Ministry of Education Academic Research Fund Tier 2 grant MOE2015-T2-2-119. W.-J. Chng. was also supported by the NMRC Clinician Scientist Investigator Award and Singapore Translational Research (STaR) Award. 2021-04-12T07:35:43Z 2021-04-12T07:35:43Z 2019 Journal Article Yan, J., Dutta, B., Hee, Y. T. & Chng, W. (2019). Towards understanding of PRC2 binding to RNA. RNA Biology, 16(2), 176-184. https://dx.doi.org/10.1080/15476286.2019.1565283 1547-6286 0000-0002-8530-8957 https://hdl.handle.net/10356/147827 10.1080/15476286.2019.1565283 30608221 2-s2.0-85061160844 2 16 176 184 en NMRC/CIRG/1343/2012 MOE2014-T3-1-006 MOE2015-T2-2-119 RNA biology © 2019 Informa UK Limited, trading as Taylor & Francis Group. All rights reserved. |
| spellingShingle | Science::Medicine Polycomb Repressive Complex 2 Chromatin Yan, Junli Dutta, Bibek Hee, Yan Ting Chng, Wee-Joo Towards understanding of PRC2 binding to RNA |
| title | Towards understanding of PRC2 binding to RNA |
| title_full | Towards understanding of PRC2 binding to RNA |
| title_fullStr | Towards understanding of PRC2 binding to RNA |
| title_full_unstemmed | Towards understanding of PRC2 binding to RNA |
| title_short | Towards understanding of PRC2 binding to RNA |
| title_sort | towards understanding of prc2 binding to rna |
| topic | Science::Medicine Polycomb Repressive Complex 2 Chromatin |
| url | https://hdl.handle.net/10356/147827 |
| work_keys_str_mv | AT yanjunli towardsunderstandingofprc2bindingtorna AT duttabibek towardsunderstandingofprc2bindingtorna AT heeyanting towardsunderstandingofprc2bindingtorna AT chngweejoo towardsunderstandingofprc2bindingtorna |