Identification and engineering of 32 membered antifungal macrolactone notonesomycins

Identification and engineering of 32 membered antifungal macrolactone notonesomycins

Notonesomycin A is a 32-membered bioactive glycosylated macrolactone known to be produced by Streptomyces aminophilus subsp. notonesogenes 647-AV1 and S. aminophilus DSM 40186. In a high throughput antifungal screening campaign, we identified an alternative notonesomycin A producing strain, Streptom...

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Bibliographic Details
Main Authors: Goh, Falicia, Zhang, Mingzi M., Lim, Tian Ru, Low, Kia Ngee, Nge, Choy Eng, Heng, Elena, Yeo, Wan Lin, Sirota, Fernanda L., Crasta, Sharon, Tan, Zann, Ng, Veronica, Leong, Chung Yan, Zhang, Huibin, Lezhava, Alexander, Chen, Swaine L., Hoon, Shawn S., Eisenhaber, Frank, Eisenhaber, Birgit, Kanagasundaram, Yoganathan, Wong, Fong T., Ng, Siew Bee
Other Authors: School of Computer Science and Engineering
Format: Journal Article
Language:English
Published: 2021
Subjects:
Engineering::Bioengineering
Natural Product
Polyketide
Online Access:https://hdl.handle.net/10356/147974

Internet

https://hdl.handle.net/10356/147974

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