Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis

Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis

The approval of bedaquiline has placed energy metabolism in the limelight as an attractive target space for tuberculosis antibiotic development. While bedaquiline inhibits the mycobacterial F1F0 ATP synthase, small molecules targeting other components of the oxidative phosphorylation pathway have be...

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Detalhes bibliográficos
Principais autores: Lee, Bei Shi, Hards, Kiel, Engelhart, Curtis A., Hasenoehrl, Erik J., Kalia, Nitin Pal, Mackenzie, Jared S., Sviriaeva, Ekaterina, Chong, Sherilyn Shi Min, Manimekalai, Malathy Sony S., Koh, Vanessa H., Chan, John, Xu, Jiayong, Alonso, Sylvie, Miller, Marvin J., Steyn, Adrie J. C., Grüber, Gerhard, Schnappinger, Dirk, Berney, Michael, Cook, Gregory M., Moraski, Garrett C., Pethe, Kevin
Outros Autores: School of Biological Sciences
Formato: Journal Article
Idioma:English
Publicado em: 2021
Assuntos:
Science::Chemistry::Biochemistry
Antibiotic-tolerance
Cytochrome bcc-aa3
Acesso em linha:https://hdl.handle.net/10356/149224

Internet

https://hdl.handle.net/10356/149224

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