Molecular mechanism of ligand bindings to Zika virus at SAM site

Molecular mechanism of ligand bindings to Zika virus at SAM site

We investigated residue-specific binding free energies using computational alanine scanning with interaction entropy method to identify hot-spots and unravel molecular basis in 3 ligand bindings to Zika SAM binding site. This approach allows one to obtain quantitatively residue-specific contribution...

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Bibliographic Details
Main Authors: Liu, Xiao, Zhao, Yang, Zhang, John Z. H.
Other Authors: School of Materials Science and Engineering
Format: Journal Article
Language:English
Published: 2021
Subjects:
Engineering::Materials
NS5 Methyltransferase
Interaction Entropy
Online Access:https://hdl.handle.net/10356/150707

Internet

https://hdl.handle.net/10356/150707

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