Thiazolidin-5-imine formation as a catalyst-free bioorthogonal reaction for protein and live cell labeling

A previously undescribed reaction involving the formation of a thiazolidin-5-imine linkage was developed for bioconjugation. Being highly specific and operating in aqueous media, this simple condensation reaction is used to chemoselectively label peptides, proteins, and living cells under physiologi...

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书目详细资料
Main Authors: Bi, Xiaobao, Yin, Juan, Rao, Chang, Balamkundu, Seetharamsing, Banerjee, Biplab, Zhang, Dingpeng, Zhang, Dawei, Dedon, Peter C., Liu, Chuan-Fa
其他作者: School of Biological Sciences
格式: Journal Article
语言:English
出版: 2021
主题:
在线阅读:https://hdl.handle.net/10356/150739
实物特征
总结:A previously undescribed reaction involving the formation of a thiazolidin-5-imine linkage was developed for bioconjugation. Being highly specific and operating in aqueous media, this simple condensation reaction is used to chemoselectively label peptides, proteins, and living cells under physiological conditions without the need to use toxic catalysts or reducing reagents.