Cell-free DNA promotes thrombin autolysis and generation of thrombin-derived C-terminal fragments

Cell-free DNA promotes thrombin autolysis and generation of thrombin-derived C-terminal fragments

Cell-free DNA (cfDNA) is the major structural component of neutrophil extracellular traps (NETs), an innate immune response to infection. Antimicrobial proteins and peptides bound to cfDNA play a critical role in the bactericidal property of NETs. Recent studies have shown that NETs have procoagulan...

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Bibliographic Details
Main Authors: Saravanan, Rathi, Choong, Yeu Khai, Lim, Chun Hwee, Lim, Li Ming, Petrlova, Jitka, Schmidtchen, Artur
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2021
Subjects:
Science::Medicine
Thrombin
Host Defense Peptides
Online Access:https://hdl.handle.net/10356/152056

Internet

https://hdl.handle.net/10356/152056

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