Targeting thioredoxin reductase with organometallics
The thioredoxin (Trx) system is a key antioxidant system to the regulation of oxidative stress in cells. Thioredoxin reductase (TrxR) is an enzyme which is central to the Trx system and is upregulated in cancer cells, making it a potential target in anti-cancer therapy. Its active site contains an S...
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| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
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Nanyang Technological University
2021
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| Online Access: | https://hdl.handle.net/10356/152387 |