GGGCTA repeats can fold into hairpins poorly unfolded by replication protein A : a possible origin of the length-dependent instability of GGGCTA variant repeats in human telomeres

GGGCTA repeats can fold into hairpins poorly unfolded by replication protein A : a possible origin of the length-dependent instability of GGGCTA variant repeats in human telomeres

Human telomeres are composed of GGGTTA repeats and interspersed with variant repeats. The GGGCTA variant motif was identified in the proximal regions of human telomeres about 10 years ago and was shown to display a length-dependent instability. In parallel, a structural study showed that four GGGCTA...

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Bibliographic Details
Main Authors: Chatain, Jean, Blond, Alain, Phan, Anh Tuân, Saintomé, Carole, Alberti, Patrizia
Other Authors: School of Physical and Mathematical Sciences
Format: Journal Article
Language:English
Published: 2022
Subjects:
Science::Biological sciences
Single-Stranded-DNA
Werner-Syndrome Protein
Online Access:https://hdl.handle.net/10356/153717

Internet

https://hdl.handle.net/10356/153717

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