A chemical biology approach reveals a dependency of glioblastoma on biotin distribution

A chemical biology approach reveals a dependency of glioblastoma on biotin distribution

Glioblastoma (GBM) is a uniformly lethal disease driven by glioma stem cells (GSCs). Here, we use a chemical biology approach to unveil previously unknown GBM dependencies. By studying sulconazole (SN) with anti-GSC properties, we find that SN disrupts biotin distribution to the carboxylases and his...

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Bibliographic Details
Main Authors: Yoon, Jeehyun, Grinchuk, Oleg V., Kannan, Srinivasaraghavan, Ang, Melgious Jin Yan, Li, Zhenglin, Tay, Emmy Xue Yun, Lok, Ker Zhing, Lee, Bernice Woon Li, Chuah, You Heng, Chia, Kimberly, Tirado-Magallanes, Roberto, Liu, Chenfei, Zhao, Haonan, Hor, Jin Hui, Lim, Jhin Jieh, Benoukraf, Touati, Toh, Tan Boon, Chow, Edward Kai-Hua, Kovalik, Jean-Paul, Ching, Jianhong, Ng, Shi-Yan, Koh, Ming Joo, Liu, Xiaogang, Verma, Chandra Shekhar, Ong, Derrick Sek Tong
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2022
Subjects:
Science::Biological sciences
Receptor-Mediated Endocytosis
Gene-Expression
Online Access:https://hdl.handle.net/10356/154365

Internet

https://hdl.handle.net/10356/154365

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