MYC overexpression leads to increased chromatin interactions at superenhancers and MYC binding sites

MYC overexpression leads to increased chromatin interactions at superenhancers and MYC binding sites

The MYC oncogene encodes for the MYC protein and is frequently dysregulated across multiple cancer cell types, making it an attractive target for cancer therapy. MYC overexpression leads to MYC binding at active enhancers, resulting in a global transcriptional amplification of active genes. Since...

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Bibliographic Details
Main Authors: See, Yi Xiang, Chen, Kaijing, Fullwood, Melissa Jane
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2022
Subjects:
Science::Biological sciences::Genetics
Science::Biological sciences::Molecular biology
Chromatin Interactions
Cancer
Online Access:https://hdl.handle.net/10356/155129

Internet

https://hdl.handle.net/10356/155129

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