MYC overexpression leads to increased chromatin interactions at superenhancers and MYC binding sites

MYC overexpression leads to increased chromatin interactions at superenhancers and MYC binding sites

The MYC oncogene encodes for the MYC protein and is frequently dysregulated across multiple cancer cell types, making it an attractive target for cancer therapy. MYC overexpression leads to MYC binding at active enhancers, resulting in a global transcriptional amplification of active genes. Since...

书目详细资料
Main Authors:	See, Yi Xiang, Chen, Kaijing, Fullwood, Melissa Jane
其他作者:	School of Biological Sciences
格式:	Journal Article
语言:	English
出版:	2022
主题:	Science::Biological sciences::Genetics Science::Biological sciences::Molecular biology Chromatin Interactions Cancer
在线阅读:	https://hdl.handle.net/10356/155129

相似书籍

MYC overexpression in cancer increases chromatin interactions at superenhancers and c-Myc binding sites
由: See, Yi Xiang
出版: (2022)

Chromatin interactions and regulatory elements in cancer : from bench to bedside
由: See, Yi Xiang, et al.
出版: (2020)

Long-distance repression by human silencers: chromatin interactions and phase separation in silencers
由: Zhang, Ying, et al.
出版: (2022)

H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions
由: Cai, Yichao, et al.
出版: (2021)

Modulation of HEK293T cells proliferation under different conditions by c-Myc overexpression.
由: Fu, XianWang.
出版: (2013)

Regulation of chromatin interactions to the MYC oncogene by long non-coding RNA PVT1 in acute myeloid leukemia cell lines
由: Nur Zahwah Asa'ad Sameer Bagharib
出版: (2018)

Reconstituted TAD-size chromatin fibers feature heterogeneous nucleosome clusters
由: Korolev, Nikolay, et al.
出版: (2023)

Engineering nucleosomes for generating diverse chromatin assemblies
由: Adhireksan, Zenita, et al.
出版: (2021)

The MYC-independent effects of BET inhibitor JQ1 on super-enhancers in cancer
由: Chia, Boon Jun
出版: (2019)

Profiling of 3D genome organization in nasopharyngeal cancer needle biopsy patient samples by a modified Hi-C approach
由: Animesh, Sambhavi, et al.
出版: (2022)

Chromatin liquid-liquid phase separation (LLPS) is regulated by ionic conditions and fiber length
由: Chen, Qinming, et al.
出版: (2023)

Embryonic stem cell differentiation is regulated by SET through interactions with p53 and β-Catenin
由: Harikumar, Arigela, et al.
出版: (2021)

Accurate identification of DNA replication origin by fusing epigenomics and chromatin interaction information
由: Dao, Fu-Ying, et al.
出版: (2023)

Chromatin architectural factors as safeguards against excessive supercoiling during DNA replication
由: Ahmed, Syed Moiz, et al.
出版: (2021)

Linker histone defines structure and self-association behaviour of the 177 bp human chromatosome
由: Wang, Sai, et al.
出版: (2021)

Chromatin loop anchors can predict transcript and exon usage
由: Zhang, Yu, et al.
出版: (2023)

How potassium came to be the dominant biological cation : of metabolism, chemiosmosis, and cation selectivity since the beginnings of life
由: Korolev, Nikolay
出版: (2022)

Near-atomic resolution structures of interdigitated nucleosome fibres
由: Adhireksan, Zenita, et al.
出版: (2021)

Expression of N-myc downstream regulated gene 4 (NDRG4) in neuroblastoma.
由: Lee, Jessica Kin-Mun.
出版: (2012)

Characterizing the nucleosome site selectivity, adduct structures and impact on chromatin for a variety of metal-based anticancer compounds and structural studies of nucleosome-linker histone interactions
由: Adhireksan, Zenita
出版: (2016)

Chromatin structuring factor HMGA2 controls subtelomere stability and cancer chemosensitivity
由: Syed Moiz Ahmed
出版: (2020)

The polyelectrolyte properties of chromatin
由: Nordenskiöld, Lars, et al.
出版: (2013)

Solid-state NMR studies of chromatin structure and dynamics
由: Prasanna, Chinmayi
出版: (2021)

Electron microscopy and biochemical analysis of native telomeric chromatin
由: Ahsan, Bilal
出版: (2019)

In vitro reconstitution and characterisation of structural and dynamic properties of telomeric chromatin
由: Wong, Sook Yi
出版: (2022)

Recognition of nucleosomes by protein factors that regulate chromatin structure and dynamics
由: Lee, Phoi Leng
出版: (2020)

Ultrastructure and nuclear architecture of telomeric chromatin revealed by correlative light and electron microscopy
由: Hübner, Barbara, et al.
出版: (2022)

Biophysical studies of recombinant chromatin and nucleosome core particle (NCP) systems interacting with lipids.
由: Berezhnoy, Nikolay.
出版: (2013)

Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation
由: Li, Guoliang, et al.
出版: (2013)

Partial desensitization of MYC2 transcription factor alters the interaction with jasmonate signaling components and affects specialized metabolism
由: Hou, Xin, et al.
出版: (2023)

Chromatin modifications associated with activation and repression of stevor multigene family of plasmodium falciparum during the trophozoite stage
由: Mushunje, Annals Tatenda
出版: (2016)

Recognition of the nucleosome by the chromatin remodeler atrx
由: Feng, Xiaoyu
出版: (2017)

Applying ChIP and ChIA-PET to identify p300, CTCF and Lamin B binding sites in stem cells
由: Sheng, Jianpeng
出版: (2009)

Overexpression of RasV12 and its role in promoting the robustness of HEK293T cells.
由: Chow, Peiyi Vicki.
出版: (2013)

Computational analysis and characterization of dysregulated chromatin interactions and RNA biology in acute myeloid leukemia
由: Kong, Lingshi
出版: (2022)

Chromatin topology defines cell identity and phenotypic transition in human cancer and fungal pathogen
由: Chen, Yao
出版: (2020)

Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth
由: Zhang, Ying, et al.
出版: (2024)

The effect of salt on oligocation-induced chromatin condensation
由: Korolev, Nikolay, et al.
出版: (2013)

Investigating chromatin folding and fibre-fibre formation
由: Lee, Kwok Kin
出版: (2014)

Modelling chromatin structure and dynamics : status and prospects
由: Korolev, Nikolay, et al.
出版: (2013)