Biallelic NF1 inactivation in high grade serous ovarian cancers from patients with neurofibromatosis type 1
Neurofibromatosis type 1 (NF1) is a multisystem disorder caused by germline heterozygous NF1 loss-of-function variants. The NF1 gene encodes neurofibromin, a RAS GTPase-activating protein, which functions by down-regulating RAS/RAF/MAPK-signalling pathways. Somatic NF1 aberrations frequently occur i...
| 主要な著者: | , , , , , , , , , , |
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| その他の著者: | |
| フォーマット: | Journal Article |
| 言語: | English |
| 出版事項: |
2022
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| 主題: | |
| オンライン･アクセス: | https://hdl.handle.net/10356/155620 |