Biallelic NF1 inactivation in high grade serous ovarian cancers from patients with neurofibromatosis type 1

Biallelic NF1 inactivation in high grade serous ovarian cancers from patients with neurofibromatosis type 1

Neurofibromatosis type 1 (NF1) is a multisystem disorder caused by germline heterozygous NF1 loss-of-function variants. The NF1 gene encodes neurofibromin, a RAS GTPase-activating protein, which functions by down-regulating RAS/RAF/MAPK-signalling pathways. Somatic NF1 aberrations frequently occur i...

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Bibliographic Details
Main Authors: Courtney, Eliza, Chan, Sock Hoai, Li, Shao Tzu, Ishak, Diana, Merchant, Khurshid, Shaw, Tarryn, Chay, Wen Yee, Chin, Felicia Hui Xian, Wong, Wai Loong, Wong, Adele, Ngeow, Joanne
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2022
Subjects:
Science::Biological sciences
Neurofbromatosis
Neurofbromin
Online Access:https://hdl.handle.net/10356/155620

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