Mycobacterium tuberculosis PanD structure-function analysis and identification of a potent pyrazinoic acid-derived enzyme inhibitor

Mycobacterium tuberculosis PanD structure-function analysis and identification of a potent pyrazinoic acid-derived enzyme inhibitor

A common strategy employed in antibacterial drug discovery is targeting of biosynthetic processes which are essential and specific for the pathogen. Specificity in particular avoids undesirable interactions with potential enzymatic counterparts in the human host, and ensures on-target toxicity. S...

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Bibliographic Details
Main Authors: Ragunathan, Priya, Cole, Malcolm, Latka, Chitra, Aragaw, Wassihun Wedajo, Hegde, Pooja, Shin, Joon, Manimekalai, Malathy Sony Subramanian, Rishikesan, Sankaranarayanan, Aldrich, Courtney C., Dick, Thomas, Grüber, Gerhard
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2022
Subjects:
Science::Biological sciences::Biochemistry
Science::Chemistry::Analytical chemistry
Tuberculosis
Mycobacteria
Pyrazinamide;
Pyrazinoic Acid
Coenzyme A
Aspartate Decarboxylase
Online Access:https://hdl.handle.net/10356/155645

Internet

https://hdl.handle.net/10356/155645

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