Mycobacterium tuberculosis PanD structure-function analysis and identification of a potent pyrazinoic acid-derived enzyme inhibitor

Mycobacterium tuberculosis PanD structure-function analysis and identification of a potent pyrazinoic acid-derived enzyme inhibitor

A common strategy employed in antibacterial drug discovery is targeting of biosynthetic processes which are essential and specific for the pathogen. Specificity in particular avoids undesirable interactions with potential enzymatic counterparts in the human host, and ensures on-target toxicity. S...

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Những tác giả chính: Ragunathan, Priya, Cole, Malcolm, Latka, Chitra, Aragaw, Wassihun Wedajo, Hegde, Pooja, Shin, Joon, Manimekalai, Malathy Sony Subramanian, Rishikesan, Sankaranarayanan, Aldrich, Courtney C., Dick, Thomas, Grüber, Gerhard
Tác giả khác: School of Biological Sciences
Định dạng: Journal Article
Ngôn ngữ:English
Được phát hành: 2022
Những chủ đề:
Science::Biological sciences::Biochemistry
Science::Chemistry::Analytical chemistry
Tuberculosis
Mycobacteria
Pyrazinamide;
Pyrazinoic Acid
Coenzyme A
Aspartate Decarboxylase
Truy cập trực tuyến:https://hdl.handle.net/10356/155645

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https://hdl.handle.net/10356/155645

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