Mycobacterium tuberculosis PanD structure-function analysis and identification of a potent pyrazinoic acid-derived enzyme inhibitor

Mycobacterium tuberculosis PanD structure-function analysis and identification of a potent pyrazinoic acid-derived enzyme inhibitor

A common strategy employed in antibacterial drug discovery is targeting of biosynthetic processes which are essential and specific for the pathogen. Specificity in particular avoids undesirable interactions with potential enzymatic counterparts in the human host, and ensures on-target toxicity. S...

書目詳細資料
Main Authors:	Ragunathan, Priya, Cole, Malcolm, Latka, Chitra, Aragaw, Wassihun Wedajo, Hegde, Pooja, Shin, Joon, Manimekalai, Malathy Sony Subramanian, Rishikesan, Sankaranarayanan, Aldrich, Courtney C., Dick, Thomas, Grüber, Gerhard
其他作者:	School of Biological Sciences
格式:	Journal Article
語言:	English
出版:	2022
主題:	Science::Biological sciences::Biochemistry Science::Chemistry::Analytical chemistry Tuberculosis Mycobacteria Pyrazinamide; Pyrazinoic Acid Coenzyme A Aspartate Decarboxylase
在線閱讀:	https://hdl.handle.net/10356/155645

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