Discovery of hyperstable noncanonical plant-derived epidermal growth factor receptor agonist and analogs

Discovery of hyperstable noncanonical plant-derived epidermal growth factor receptor agonist and analogs

Here, we report the discovery of the first plant- derived and noncanonical epidermal growth factor receptor (EGFR) agonist, the 36-residue bleogen pB1 from Pereskia bleo of the Cactaceae family. We show that bleogen pB1 is a low-affinity EGFR agonist using a suite of chemical, biochemical, cellu...

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Bibliographic Details
Main Authors: Loo, Shining, Kam, Antony, Li, Binbin, Feng, Nan, Wang, Xiaoliang, Tam, James P.
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2022
Subjects:
Science::Biological sciences::Biochemistry
Science::Medicine
Amino Acid Motifs
Epidermal Growth Factor Receptor
Online Access:https://hdl.handle.net/10356/156118

Internet

https://hdl.handle.net/10356/156118

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