Interdomain flexibility of Chikungunya virus nsP2 helicase-protease differentially influences viral RNA replication and infectivity

Interdomain flexibility of Chikungunya virus nsP2 helicase-protease differentially influences viral RNA replication and infectivity

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for chikungunya fever. Nonstructural protein 2 (nsP2), a multifunctional protein essential for viral replication, has an N-terminal helicase region (nsP2h), which has both nucleotide triphosphatase and RNA triphosphatase activities...

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Bibliographic Details
Main Authors: Law, Yee-Song, Wang, Sainan, Tan, Yaw Bia, Shih, Orion, Utt, Age, Goh, Wei Yang, Lian, Bing-Jun, Chen, Ming Wei, Jeng, U-Ser, Merits, Andres, Luo, Dahai
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2022
Subjects:
Science::Biological sciences
Alphavirus
Nonstructural Protein 2
Online Access:https://hdl.handle.net/10356/157045

Internet

https://hdl.handle.net/10356/157045

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