Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX

Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX

Epithelial tissues are primed to respond to insults by activating epithelial cell motility and rapid inflammation. Such responses are also elicited upon overexpression of the membrane-bound protease, Matriptase, or mutation of its inhibitor, Hai1. Unrestricted Matriptase activity also predisposes to...

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Bibliographic Details
Main Authors: Ma, Jiajia, Scott, Claire A., Ho, Ying Na, Mahabaleshwar, Harsha, Marsay, Katherine S., Zhang, Changqing, Teow, Christopher K. J., Ng, Ser Sue, Zhang, Weibin, Tergaonkar, Vinay, Partridge, Lynda J., Roy, Sudipto, Amaya, Enrique, Carney, Tom J.
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2022
Subjects:
Science::Medicine
Epidermis
Epithelia
Online Access:https://hdl.handle.net/10356/159382

Internet

https://hdl.handle.net/10356/159382

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