Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis

Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis

Background and aims: Aging is the primary risk factor for cardiovascular disease (CVD), but the mechanisms underlying age-linked atherosclerosis remain unclear. We previously observed that long-lived vascular matrix proteins can acquire 'gain-of-function' isoDGR motifs that might play a ro...

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Bibliographic Details
Main Authors: Park, Jung Eun, JebaMercy, Gnanasekaran, Pazhanchamy, Kalailingam, Guo, Xue, Ngan, SoFong Cam, Liou, Ken Cheng Kang, Soe, Lynn EinSi, Ng, Ser Sue, Meng, Wei, Lim, Su Chi, Leow, Melvin Khee-Shing, Richards, A. Mark, Pennington, Daniel J., de Kleijn, Dominique P. V., Sorokin, Vitaly, Ho, Hee Hwa, McCarthy, Neil E., Sze, Siu Kwan
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2022
Subjects:
Science::Biological sciences
Science::Medicine
Atherosclerosis
Vascular Inflammation
Online Access:https://hdl.handle.net/10356/159531

Internet

https://hdl.handle.net/10356/159531

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