The ratio of nicotinic acid to nicotinamide as a microbial biomarker for assessing cell therapy product sterility

Controlling microbial risks in cell therapy products (CTPs) is important for product safety. Here, we identified the nicotinic acid (NA) to nicotinamide (NAM) ratio as a biomarker that detects a broad spectrum of microbial contaminants in cell cultures. We separately added six different bacterial sp...

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Bibliographic Details
Main Authors: Huang, Jiayi, Cui, Liang, Natarajan, Meenubharathi, Barone, Paul W., Wolfrum, Jacqueline M., Lee, Yie Hou, Rice, Scott A., Springs, Stacy L.
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2022
Subjects:
Online Access:https://hdl.handle.net/10356/160886