Structural and biochemical mechanisms of NLRP1 inhibition by DPP9

Structural and biochemical mechanisms of NLRP1 inhibition by DPP9

Nucleotide-binding domain, leucine-rich repeat receptors (NLRs) mediate innate immunity by forming inflammasomes. Activation of the NLR protein NLRP1 requires autocleavage within its function-to-find domain (FIIND)1-7. In resting cells, the dipeptidyl peptidases DPP8 and DPP9 interact with the FIIND...

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Bibliographic Details
Main Authors: Huang, Menghang, Zhang, Xiaoxiao, Toh, Gee Ann, Gong, Qin, Wang, Jia, Han, Zhifu, Wu, Bin, Zhong, Franklin, Chai, Jijie
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2022
Subjects:
Science::Biological sciences
Inflammasome
Domain
Online Access:https://hdl.handle.net/10356/161397

Internet

https://hdl.handle.net/10356/161397

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