Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug
We report two structures of the human voltage-gated potassium channel (Kv) Kv1.3 in immune cells alone (apo-Kv1.3) and bound to an immunomodulatory drug called dalazatide (dalazatide-Kv1.3). Both the apo-Kv1.3 and dalazatide-Kv1.3 structures are in an activated state based on their depolarized volta...
| Автори: | , , , , , , , , , , |
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| Інші автори: | |
| Формат: | Journal Article |
| Мова: | English |
| Опубліковано: |
2022
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| Предмети: | |
| Онлайн доступ: | https://hdl.handle.net/10356/162571 |