The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans

The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans

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Metabolic diseases often share common traits, including accumulation of unfolded proteins in the endoplasmic reticulum (ER). Upon ER stress, the unfolded protein response (UPR) is activated to limit cellular damage which weakens with age. Here, we show that Caenorhabditis elegans fed a bacterial die...

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Bibliographic Details
Main Authors: Beaudoin-Chabot, Caroline, Wang, Lei, Celik, Cenk, Aishah Tul-Firdaus Abdul Khalid, Thalappilly, Subhash, Xu, Shiyi, Koh, Jhee Hong, Lim, Venus Wen Xuan, Low, Ann Don, Thibault, Guillaume
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2022
Subjects:
Science::Medicine
Ageing
Stress
Online Access:https://hdl.handle.net/10356/162675

Internet

https://hdl.handle.net/10356/162675

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