Binding properties of the anti-TB drugs bedaquiline and TBAJ-876 to a mycobacterial F-ATP synthase

Binding properties of the anti-TB drugs bedaquiline and TBAJ-876 to a mycobacterial F-ATP synthase

Tuberculosis (TB), the deadly disease caused by Mycobacterium tuberculosis (Mtb), kills more people worldwide than any other bacterial infectious disease. There has been a recent resurgence of TB drug discovery activities, resulting in the identification of a number of novel enzyme inhibitors. Many...

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Bibliographic Details
Main Authors: Krah, Alexander, Grüber, Gerhard, Bond, Peter. J.
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2022
Subjects:
Science::Biological sciences::Biophysics
Mycobacteria
F-ATP Synthase
Diarylquinolines
Bedaquiline
TBAJ-876
Molecular Dynamics Simulations
Online Access:https://hdl.handle.net/10356/163131

Internet

https://hdl.handle.net/10356/163131

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