Expression, purification and crystallization of DynE8 involved in the biosynthesis of an antitumor warhead.

Enediynes are natural products that catalyze DNA breakage and hence are potential anticancer drugs. The polyketide backbone of the enediyne warhead ring strucure is synthesized by enediyne polyketide synthases. In this work, the enediyne polyketide synthase for dynemicin, DYNE8, was expressed, purif...

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Bibliografski detalji
Glavni autor: Chen, Ming Wei.
Daljnji autori: Julien Lescar
Format: Final Year Project (FYP)
Jezik:English
Izdano: 2009
Teme:
Online pristup:http://hdl.handle.net/10356/16344