Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor-induced dipeptidase-1 expression and glutathione depletion

Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor-induced dipeptidase-1 expression and glutathione depletion

Dexamethasone is widely used as an immunosuppressive therapy and recently as COVID-19 treatment. Here, we demonstrate that dexamethasone sensitizes to ferroptosis, a form of iron-catalyzed necrosis, previously suggested to contribute to diseases such as acute kidney injury, myocardial infarction, an...

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Bibliographic Details
Main Authors: von Mässenhausen, Anne, Gonzalez, Nadia Zamora, Maremonti, Francesca, Belavgeni, Alexia, Tonnus, Wulf, Meyer, Claudia, Beer, Kristina, Hannani, Monica T., Lau, Arthur, Peitzsch, Mirko, Hoppenz, Paul, Locke, Sophie, Chavakis, Triantafyllos, Kramann, Rafael, Muruve, Daniel A., Hugo, Christian, Bornstein, Stefan R., Linkermann, Andreas
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2023
Subjects:
Science::Medicine
Dexamethasones
Glucocorticoid Receptor
Online Access:https://hdl.handle.net/10356/164371

Internet

https://hdl.handle.net/10356/164371

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