Dissecting the role of diabetes-associated PAX4 polymorphisms in modulating pancreatic beta cell development and function
Diabetes is a major chronic disease with an excessive healthcare burden on society. A missense variant within the coding region of the PAX4 gene (rs2233580, R192H) is associated with T2D in East Asians. In mice, Pax4 is essential for beta cell formation but neither the role of diabetes associate...
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| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
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Nanyang Technological University
2023
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| Online Access: | https://hdl.handle.net/10356/164374 |