Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways

Although glucagon secretion is perturbed in both T1D and T2D, the pathophysiological changes in individual pancreatic alpha cells are still obscure. Using recently curated single-cell RNASeq data from T1D or T2D donors and their controls, we identified alpha cell transcriptomic alterations consisten...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Bosi, Emanuele, Marchetti, Piero, Rutter, Guy Allen, Eizirik, Decio Laks
अन्य लेखक: Lee Kong Chian School of Medicine (LKCMedicine)
स्वरूप: Journal Article
भाषा:English
प्रकाशित: 2023
विषय:
ऑनलाइन पहुंच:https://hdl.handle.net/10356/164615