Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism
Cold affects many aspects of biology, medicine, agriculture, and industry. Here, we identify a conserved endoplasmic reticulum (ER) stress response, distinct from the canonical unfolded protein response, that maintains lipid homeostasis during extreme cold. We establish that the ER stress sensor IRE...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/164688 |
| _version_ | 1811679359708168192 |
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| author | Dudkevich, Reut Koh, Jhee Hong Beaudoin-Chabot, Caroline Celik, Cenk Lebenthal-Loinger, Ilana Karako-Lampert, Sarit Syed Ahmad-Albukhari Thibault, Guillaume Henis-Korenblit, Sivan |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Dudkevich, Reut Koh, Jhee Hong Beaudoin-Chabot, Caroline Celik, Cenk Lebenthal-Loinger, Ilana Karako-Lampert, Sarit Syed Ahmad-Albukhari Thibault, Guillaume Henis-Korenblit, Sivan |
| author_sort | Dudkevich, Reut |
| collection | NTU |
| description | Cold affects many aspects of biology, medicine, agriculture, and industry. Here, we identify a conserved endoplasmic reticulum (ER) stress response, distinct from the canonical unfolded protein response, that maintains lipid homeostasis during extreme cold. We establish that the ER stress sensor IRE-1 is critical for resistance to extreme cold and activated by cold temperature. Specifically, neuronal IRE-1 signals through JNK-1 and neuropeptide signaling to regulate lipid composition within the animal. This cold-response pathway can be bypassed by dietary supplementation with unsaturated fatty acids. Altogether, our findings define an ER-centric conserved organism-wide cold stress response, consisting of molecular neuronal sensors, effectors, and signaling moieties, which control adaptation to cold conditions in the organism. Better understanding of the molecular basis of this stress response is crucial for the optimal use of cold conditions on live organisms and manipulation of lipid saturation homeostasis, which is perturbed in human pathologies. |
| first_indexed | 2024-10-01T03:07:54Z |
| format | Journal Article |
| id | ntu-10356/164688 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:07:54Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1646882023-02-28T17:14:00Z Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism Dudkevich, Reut Koh, Jhee Hong Beaudoin-Chabot, Caroline Celik, Cenk Lebenthal-Loinger, Ilana Karako-Lampert, Sarit Syed Ahmad-Albukhari Thibault, Guillaume Henis-Korenblit, Sivan School of Biological Sciences Institute of Molecular and Cell Biology, A*STAR Science::Medicine Caenorhabditis Elegans ER Stress RNA-Seq Cold affects many aspects of biology, medicine, agriculture, and industry. Here, we identify a conserved endoplasmic reticulum (ER) stress response, distinct from the canonical unfolded protein response, that maintains lipid homeostasis during extreme cold. We establish that the ER stress sensor IRE-1 is critical for resistance to extreme cold and activated by cold temperature. Specifically, neuronal IRE-1 signals through JNK-1 and neuropeptide signaling to regulate lipid composition within the animal. This cold-response pathway can be bypassed by dietary supplementation with unsaturated fatty acids. Altogether, our findings define an ER-centric conserved organism-wide cold stress response, consisting of molecular neuronal sensors, effectors, and signaling moieties, which control adaptation to cold conditions in the organism. Better understanding of the molecular basis of this stress response is crucial for the optimal use of cold conditions on live organisms and manipulation of lipid saturation homeostasis, which is perturbed in human pathologies. Ministry of Education (MOE) Ministry of Health (MOH) National Medical Research Council (NMRC) Published version This work was supported by funds from the Israel Science Foundation (ISF grant no. 689/19 to S.H.K.), the traveling fellowship from The Company of Biologists (JCSTF18118 to R.D.), the Singapore Ministry of Education Academic Research Fund Tier 3 (MOE-MOET32020-0001 to G.T.), the Ministry of Health, Singapore, National Medical Research Council Open Fund Individual Research Grant (MOH-000566 to G.T.), and the S Research Scholarship to J.H.K. (predoctoral fellowship). 2023-02-10T01:32:52Z 2023-02-10T01:32:52Z 2022 Journal Article Dudkevich, R., Koh, J. H., Beaudoin-Chabot, C., Celik, C., Lebenthal-Loinger, I., Karako-Lampert, S., Syed Ahmad-Albukhari, Thibault, G. & Henis-Korenblit, S. (2022). Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism. Cell Reports, 41(9), 111739-. https://dx.doi.org/10.1016/j.celrep.2022.111739 2211-1247 https://hdl.handle.net/10356/164688 10.1016/j.celrep.2022.111739 36450261 2-s2.0-85142507175 9 41 111739 en MOE-MOET32020-0001 MOH-000566 Cell Reports © 2022 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). application/pdf |
| spellingShingle | Science::Medicine Caenorhabditis Elegans ER Stress RNA-Seq Dudkevich, Reut Koh, Jhee Hong Beaudoin-Chabot, Caroline Celik, Cenk Lebenthal-Loinger, Ilana Karako-Lampert, Sarit Syed Ahmad-Albukhari Thibault, Guillaume Henis-Korenblit, Sivan Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism |
| title | Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism |
| title_full | Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism |
| title_fullStr | Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism |
| title_full_unstemmed | Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism |
| title_short | Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism |
| title_sort | neuronal ire 1 coordinates an organism wide cold stress response by regulating fat metabolism |
| topic | Science::Medicine Caenorhabditis Elegans ER Stress RNA-Seq |
| url | https://hdl.handle.net/10356/164688 |
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