Broaden the applications of peptidyl asparaginyl ligases
Peptidyl asparaginyl ligases (PALs) are highly active enzymes that catalyse peptide ligation reactions through transpeptidation. To further increase the utility of PALs, I have successfully designed an unnatural analogue of asparagine, Asn(OH), as the P1 substrate of these ligases. Using Asn(OH)-med...
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| Format: | Thesis-Doctor of Philosophy |
| Jezik: | English |
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Nanyang Technological University
2023
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| Online dostop: | https://hdl.handle.net/10356/165731 |