The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi

Chronic obstructive pulmonary disease (COPD) is characterised by airflow limitation and infective exacerbations, however, in-vitro model systems for the study of host-pathogen interaction at the individual level are lacking. Here, we describe the establishment of nasopharyngeal and bronchial organoi...

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Main Authors: Chan, Louisa L. Y., Anderson, Danielle E., Cheng, Hong Sheng, Ivan, Fransiskus Xaverius, Chen, Si, Kang, Adrian E. Z., Foo, Randy, Gamage, Akshamal M., Tiew, Pei Yee, Koh, Mariko Siyue, Lee, Ken Cheah Hooi, Nichol, Kristy, Pathinayake, Prabuddha S., Chan, Yik Lung, Yeo, Tsin Wen, Oliver, Brian G., Wark, Peter A. B., Liu, Linbo, Tan, Nguan Soon, Wang, Lin-Fa, Chotirmall, Sanjay Haresh
其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
格式: Journal Article
语言:English
出版: 2023
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在线阅读:https://hdl.handle.net/10356/168660