Population-specific positive selection on low CR1 expression in malaria-endemic regions

Complement Receptor Type 1 (CR1) is a malaria-associated gene that encodes a transmembrane receptor of erythrocytes and is crucial for malaria parasite invasion. The expression of CR1 contributes to the rosetting of erythrocytes in the brain bloodstream, causing cerebral malaria, the most severe for...

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Bibliographic Details
Main Authors: Lorenzini, Paolo Alberto, Gusareva, Elena S., Ghosh, Amit Gourav, Nurul Adilah Binte Ramli, Preiser, Peter Rainer, Kim, Hie Lim
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2023
Subjects:
Online Access:https://hdl.handle.net/10356/168813