Favorable preclinical pharmacological profile of a novel antimalarial pyrrolizidinylmethyl derivative of 4-amino-7-chloroquinoline with potent In vitro and In vivo activities

Favorable preclinical pharmacological profile of a novel antimalarial pyrrolizidinylmethyl derivative of 4-amino-7-chloroquinoline with potent In vitro and In vivo activities

The 4-aminoquinoline drugs, such as chloroquine (CQ), amodiaquine or piperaquine, are still commonly used for malaria treatment, either alone (CQ) or in combination with artemisinin derivatives. We previously described the excellent in vitro activity of a novel pyrrolizidinylmethyl derivative of 4-a...

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Bibliographic Details
Main Authors: Basilico, Nicoletta, Parapini, Silvia, D'Alessandro, Sarah, Misiano, Paola, Romeo, Sergio, Dondio, Giulio, Yardley, Vanessa, Vivas, Livia, Nasser, Shereen, Renia, Laurent, Russell, Bruce, Suwanarusk, Rossarin, Nosten, François, Sparatore, Anna, Taramelli, Donatella
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2023
Subjects:
Science::Medicine
Malaria
Drug Discovery
Online Access:https://hdl.handle.net/10356/169386

Internet

https://hdl.handle.net/10356/169386

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