Conditional knockout of hypoxia-inducible factor 1-alpha in tumor-infiltrating neutrophils protects against pancreatic ductal adenocarcinoma

Conditional knockout of hypoxia-inducible factor 1-alpha in tumor-infiltrating neutrophils protects against pancreatic ductal adenocarcinoma

Large numbers of neutrophils infiltrate tumors and comprise a notable component of the inflammatory tumor microenvironment. While it is established that tumor cells exhibit the Warburg effect for energy production, the contribution of the neutrophil metabolic state to tumorigenesis is unknown. Here,...

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Bibliographic Details
Main Authors: Sieow, Je Lin, Leong, Penny Hweixian, Gun, Sin Yee, Tan, Ling Qiao, Duan, Kaibo, Yeong, Joe Poh Sheng, Pang, Angela, Lim, Diana, Toh, Han Chong, Lim, Tony Kiat Hon, Engleman, Edgar, Rotzschke, Olaf, Ng, Lai Guan, Chen, Jinmiao, Tan, Suet Mien, Wong, Siew Cheng
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2023
Subjects:
Science::Biological sciences
Neutrophils
Pancreatic Cancer
Online Access:https://hdl.handle.net/10356/169561

Internet

https://hdl.handle.net/10356/169561

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