Identification of mechanism of cancer-cell-specific reactivation of hTERT offers therapeutic opportunities for blocking telomerase specifically in human colorectal cancer

Identification of mechanism of cancer-cell-specific reactivation of hTERT offers therapeutic opportunities for blocking telomerase specifically in human colorectal cancer

Transcriptional reactivation of hTERT is the limiting step in tumorigenesis. While mutations in hTERT promoter present in 19% of cancers are recognized as key drivers of hTERT reactivation, mechanisms by which wildtype hTERT (WT-hTERT) promoter is reactivated, in majority of human cancers, remain un...

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Bibliographic Details
Main Authors: Akıncılar, Semih Can, Chua, Joelle Yi Heng, Ng, Qin Feng, Chan, Claire Hian Tzer, Eslami-S, Zahra, Chen, Kaijing, Low, Joo-Leng, Arumugam, Surendar, Aswad, Luay, Chua, Clarinda, Tan, Iain Beehuat, DasGupta, Ramanuj, Fullwood, Melissa Jane, Tergaonkar, Vinay
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2023
Subjects:
Science::Medicine
Chromatin
Colorectal Neoplasms
Online Access:https://hdl.handle.net/10356/169656

Internet

https://hdl.handle.net/10356/169656

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