Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex

Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex

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An attractive approach to target intracellular macromolecular interfaces and to model putative drug interactions is to design small high-affinity proteins. Variable domains of the immunoglobulin heavy chain (VH domains) are ideal miniproteins, but their development has been restricted by poor intrac...

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Bibliographic Details
Main Authors: Frosi, Yuri, Lin, Yen-Chu, Jiang, Shimin, Ramlan, Siti Radhiah, Hew, Kelly, Engman, Alf Henrik, Pillai, Anil, Yeung, Kit, Cheng, Yue Xiang, Cornvik, Tobias, Nordlund, Par, Goh, Megan, Lama, Dilraj, Gates, Zachary P., Verma, Chandra Shekhar, Thean, Dawn, Lane, David P., Asial, Ignacio, Brown, Christopher J.
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2023
Subjects:
Engineering
Cell Surface Display Techniques
Eukaryotic Initiation Factor-4E
Online Access:https://hdl.handle.net/10356/170835

Internet

https://hdl.handle.net/10356/170835

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