Gasdermin D-deficient mice are hypersensitive to acute kidney injury

Gasdermin D-deficient mice are hypersensitive to acute kidney injury

Signaling pathways of regulated necrosis, such as necroptosis and ferroptosis, contribute to acute kidney injury (AKI), but the role of pyroptosis is unclear. Pyroptosis is mediated by the pore-forming protein gasdermin D (GSDMD). Here, we report a specific pattern of GSDMD-protein expression in the...

Full description

Bibliographic Details
Main Authors: Tonnus, Wulf, Maremonti, Francesca, Belavgeni, Alexia, Latk, Markus, Kusunoki, Yoshihiro, Brucker, Anne, Mässenhausen, Anne von, Meyer, Claudia, Locke, Sophie, Gembardt, Florian, Beer, Kristina, Hoppenz, Paul, Becker, Jan U., Hugo, Christian, Anders, Hans-Joachim, Bornstein, Stefan R., Shao, Feng, Linkermann, Andreas
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2023
Subjects:
Science::Medicine
Acute Kidney Tubule Necrosis
Renal Ischemia Reperfusion Injury
Online Access:https://hdl.handle.net/10356/171278

Internet

https://hdl.handle.net/10356/171278

Similar Items