Diphtheria toxin activates ribotoxic stress and NLRP1 inflammasome-driven pyroptosis

Diphtheria toxin activates ribotoxic stress and NLRP1 inflammasome-driven pyroptosis

The ZAKα-driven ribotoxic stress response (RSR) is activated by ribosome stalling and/or collisions. Recent work demonstrates that RSR also plays a role in innate immunity by activating the human NLRP1 inflammasome. Here, we report that ZAKα and NLRP1 sense bacterial exotoxins that target ribosome e...

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Bibliografski detalji
Glavni autori: Robinson, Kim Samirah, Toh, Gee Ann, Muhammad Jasrie Firdaus, Tham, Khek Chian, Rozario, Pritisha, Lim, Chrissie K., Toh, Ying Xiu, Lau, Zhi Heng, Binder, Sophie Charlotte, Mayer, Jacob, Bonnard, Carine, Schmidt, Florian I., Common, John E. A., Zhong, Franklin
Daljnji autori: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Jezik:English
Izdano: 2023
Teme:
Science::Medicine
Diphtheria Toxin
Inflammasome
Online pristup:https://hdl.handle.net/10356/171554

Internet

https://hdl.handle.net/10356/171554

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